Cellular Swelling II

The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular Cl(-) that is required for neuronal swelling and death. Pharmacological and si...

Reproducibility after de-swelling and re-swelling

Bulking II: Classifications of cellular automata

This paper is the second part of a series of two papers dealing with bulking: a way to define quasi-order on cellular automata by comparing space-time diagrams up to rescaling. In the present paper, we introduce three notions of simulation between cellular automata and study the quasi-order structures induced by these simulation relations on the whole set of cellular automata. Various aspects o...

Limit Measures for Affine Cellular Automata II

If M is a monoid, and A is an abelian group, then A is a compact abelian group; a linear cellular automaton (LCA) is a continuous endomorphism F : A −→ A that commutes with all shift maps. If F is diffusive, and μ is a harmonically mixing (HM) probability measure on A, then the sequence {Fμ}N=1 weak*-converges to the Haar measure on A, in density. Fully supported Markov measures on A are HM, an...

Mechanism of Cellular Swelling Induced by Extracellular Lactic Acidosis in Neuroblastoma-Glioma Hybrid

The mechanism of cellular swelling induced by extracellular lactic acidosis and the effect of diuretics were studied using neuroblastoma-glioma hybrid (NG10815) cells. The cells were incubated in one of three lactate concentrations (0,15, or 30 mM), each of which was randomized to one of three pH groups (7.4, 6.2, or 5.0). Analysis of the swelling was measured using a Coulter counter technique....